The first and only  licensed-to-mix PCV2 and PRRS vaccine combination, one single dose of 1ml, to protect against two of the most devastating viral pig diseases.

PCV2 infection decreases the efficiency of the immune system, potentially reducing its response to vaccines¹, as well as increasing susceptibility to other infections. Depending on severity of disease, the economic impact is estimated to be between £8.10 and £84.10 loss per pig².

PRRS virus infects  immune cells and compromises the efficiency of the immune response, especially in the lungs³. This leads to poor reproductive performance in breeding herds, as well as reduced growth and increased respiratory disease and mortality in growing pigs. PRRS disease impact on farm profits are around -19.1% and are still understimated, while the total annual costs of PRRS in Europe is estimated to be as much as € 1.5 bn⁵.

In the field, respiratory problems in pigs are rarely caused by a single pathogen. Usually, several pathogens are acting at the same time which, combined with inadequate management and environmental factors leads to the condition known as porcine respiratory disease complex (PRDC).

Diagnostic data from the Iowa State University Veterinary Diagnostic Laboratory indicates that a mixed infection of PPRS and PCV2 is one of the most common co-infections under current field conditions, resulting in pork production losses through reduced weight gain and respiratory disease in growing pigs⁶.


The mixability of Ingelvac CircoFLEX® and Ingelvac PRRSFLEX® EU was confirmed in studies evaluating the in-use stability over 4 hours of PRRS MLVs reconstituted.

1. Opriessnig T, McKeown NE, Harmon KL, Meng XJ, Halbur PG. (2006) Porcine circovirus type 2 infection decreases the efficacy of a modified live porcine reproductive and respiratory syndrome virus vaccine. Clin Vaccine Immunol. 13(8):923-929.

2. Alarcon P, Rushton J, Wieland B. (2013) Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England – an economic disease model. Prev Vet Med. Jun 1;110(2):88-102.

3. Porcine Reproductive and Respiratory Syndrome (PRRS); Accessed Dec 2021.

4. Renken, C., Nathues, C., Swam, H. et al. (2021) Application of an economic calculator to determine the cost of porcine reproductive and respiratory syndrome at farm-level in 21 pig herds in Germany. Porc Health Manag 7, 3.

5. De Paz (2015) Accessed Jan 2021.

6. Trevisan G, Schwartz KJ, Burrough ER, et al (2021). Visualization and application of disease diagnosis codes for population health management using porcine diseases as a model. J Vet Diagn Invest. May;33(3):428-438.

7. Duran, C.O.G. and Strachan, W.D. 2021. In-use stability of PRRS MLVs when mixed with PCV2 vaccines. Allen D. Leman Swine Conference Research Abstracts; p89.